The greatest risk in life is to waste it by not seeking to follow God's plan, Pope Leo XIV said, proclaiming two new saints — two young laymen of the 20th and 21st centuries.

"Sts. Pier Giorgio Frassati and Carlo Acutis are an invitation to all of us, especially young people, not to squander our lives, but to direct them upward and make them masterpieces," the Pope said in canonizing the two today.

"The simple but winning formula of their holiness," he said, is accessible to everyone at any time. "They encourage us with their words: 'Not I, but God,' as Carlo used to say. And Pier Giorgio: 'If you have God at the centre of all your actions, then you will reach the end.' "

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Before canonizing the first saints of his pontificate, Pope Leo greeted the more than 80,000 faithful who had gathered early in St. Peter's Square because he wanted to share his joy with them before the start of the solemn ceremony.

"Brothers and sisters, today is a wonderful celebration for all of Italy, for the whole Church, for the whole world," he said before the Mass.

"While the celebration is very solemn, it is also a day of great joy, and I wanted to greet especially the many young people who have come for this holy Mass," he said, also greeting the families of the soon-to-be saints and the associations and communities to which the young men had belonged.

Pope Leo asked that everyone "feel in our hearts the same thing that Pier Giorgio and Carlo experienced: this love for Jesus Christ, especially in the Eucharist, but also in the poor, in our brothers and sisters."

"All of you, all of us, are also called to be saints," he said, before leaving to prepare for Mass and paying homage to a statue of Mary with baby Jesus and the reliquaries containing the relics of the two young men.

In his homily, the Pope underlined Jesus' call in the day's Gospel reading "to abandon ourselves without hesitation to the adventure that He offers us, with the intelligence and strength that comes from His Spirit, that we can receive to the extent that we empty ourselves of the things and ideas to which we are attached, in order to listen to His word."

That is what the two new saints did and what every disciple of Christ is called to do, he said.

Many people, especially when they are young, he said, face a kind of "crossroads" in life when they reflect on what to do with their life.

The saints of the Church are often portrayed as "great figures, forgetting that for them it all began when, while still young, they said 'yes' to God and gave themselves to Him completely, keeping nothing for themselves," the Pope said. "Today we look to St. Pier Giorgio Frassati and St. Carlo Acutis: a young man from the early 20th century and a teenager from our own day, both in love with Jesus and ready to give everything for Him." 

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Pope Leo then dedicated a large portion of his homily to sharing quotes from the two and details of their lives, which is something Pope Francis had shifted away from, preferring to focus more on the day's readings.

"Pier Giorgio's life is a beacon for lay spirituality," Pope Leo said.

"For him, faith was not a private devotion, but it was driven by the power of the Gospel and his membership in ecclesial associations," he said. "He was also generously committed to society, contributed to political life and devoted himself ardently to the service of the poor.

"Carlo, for his part, encountered Jesus in his family, thanks to his parents, Andrea and Antonia — who are here today with his two siblings, Francesca and Michele," he said, as the crowd applauded, and Antonia smiled shyly at the camera.

St. Acutis also encountered Jesus at the Jesuit-run school he attended and "above all in the sacraments celebrated in the parish community," he said. "He grew up naturally integrating prayer, sport, study and charity into his days as a child and young man."

The Pope said the new saints "cultivated their love for God and for their brothers and sisters through simple acts, available to everyone: daily Mass, prayer and especially Eucharistic adoration."

St. Frassati was born April 6, 1901, in Turin and died there July 4, 1925, of polio at the age of 24. St. Acutis was born to Italian parents May 3, 1991, in London and died in Monza, Italy, Oct. 12, 2006, of leukemia at the age of 15.

The Pope said that "even when illness struck them and cut short their young lives, not even this stopped them nor prevented them from loving, offering themselves to God, blessing Him and praying to Him for themselves and for everyone."

Several family members and people closely associated with the new saints attended the Mass, along with dignitaries, such as Italian President Sergio Mattarella.

St. Acutis' parents and his twin siblings, who were born four years after their brother died, were present and together brought the Pope the offertory gifts. Michele also did the first reading at the Mass in English.

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Valeria Valverde, who read the first prayer of the faithful, is a young Costa Rican woman who suffered a severe head injury while living in Italy. It was her unexplained healing that provided the second miracle needed for St. Acutis' canonization.

St. Frassati was active with Catholic Action, the St. Vincent de Paul Society, the Italian Catholic University Federation and the Dominican Third Order. Lorenzo Zardi, vice president of the youth group of Italy's Catholic Action read the second reading at the Mass and Michele Tridente, the secretary general of the lay movement, also presented the Pope with offertory gifts.